I upgraded my laptop, an old Asus, from Fedora 9 to 10 just this week. I have to say that it’s great. To start I now have the latest OpenOffice.org, version 3, though not had chance to use it. I’m looking forward to the latest GIMP and Inkscape too.
The big difference that I tested was recognising my digital camera, a Nikon S600. This camera doesn’t act as a mass storage device, so under F9 I had to drop to a command and connect to it. This is fixed in F10, with the camera running in PTP mode. Plug it in and it automatically appears and is browsable. I’m working through testing other stuff. So far the other big win is that I can now use the SD card slot, not just for SD, I also find that SDHC works.
Gnome is looking good too. I ran with the Echo icon set in F9 and that has carried over. The upgrade was painless and has maintained everything as far as I can tell.